When connected to the same bus, various combinations of USB devices experience intermittent difficulties, or simply do not work. If using Twitch and another high bandwidth USB device, positive results will be found from unplugging the other device, or plugging it into another USB bus.
Multiple USB devices will not be able to compete for the relevant amount of bandwidth they require and therefore need to be used on separate USB buses.
To resolve any problems with Twitch, please ensure each high bandwidth device has it's own USB bus.
If your computer has a single USB bus, adding a USB interface card provides a second USB bus. Without a second USB bus, you may have to completely disconnect one high bandwidth USB device in order to utilise another.
Click here if you want to identify which devices are connected to specific buses / hubs.